"Synthesis and Studies into Conformation, Self-Assembly, and Applications of Peptide-Dye Conjugates"
Christina Gallis Forties, Ph.D.'05 (biochemistry) returns to the Nazareth College campus as part of the Department of Chemistry and Biochemistry's Spring Seminar Series.
Peptide-based systems have the potential to vastly change medicine and technology as we continue to learn more about their ability to self-assemble, and how the assembled structures can be modified for further applications. With the possibility of a peptide assembly to carry a guest molecule or pharmaceutical, we can also imagine the assembly being tracked through the body by incorporating a fluorescent molecule, and then potentially directed through the body for a more systematic drug delivery process.
In light of the potential these systems hold for the improvement of drug delivery and detection, a peptide design evolved as inspired by the collective work of Shao and coworkers, particularly the example where short dilysine peptide systems were functionalized with a p-stacking molecule and self-assembled to nanofibrils and ribbons. The work here describes several similar systems that are modified with an indocyanine green derivative that was thought to be a p-stacking initiator to drive self-assembly, while also acting as a near-IR agent, in hopes of fashioning structures of both efficiency and practicality.
Refreshments will be served.
Christina is a Rochester native and 2001 graduate of Irondequoit High School. She began her career at Nazareth College in 2001 and participated in undergraduate research with Dr. Timm Knoerzer, formerly at Nazareth College, and Dr. John Chisholm at Syracuse University, prior to graduation with a biochemistry degree in 2005. She then attended graduate school for organic chemistry at The Ohio State University in Columbus, Ohio, receiving a master's degree in 2008 and a doctorate in 2011. She now lives in Ithaca, NY with her husband, Robert, who holds a doctorate in physics.
- Sponsored By:
- Department of Chemistry and Biochemistry
- Contact Information:
- Stephen Beecher, Ph.D. Department of Chemistry and Biochemistry firstname.lastname@example.org 585-389-2581