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Department of Chemistry and Biochemistry Fall Seminar Series

  • Time:

    1:30 p.m.
  • Date:

    Friday, November 11, 2011
  • Location:

    Smyth Hall, Room 383

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"Structural Analysis of HIV-1 Viral Entry Inhibitors"

Postdoctoral Research from Johns Hopkins University

Stephen Tajc, Ph.D.
Assistant Professor
Department of Chemistry and Biochemistry
Nazareth College

The World Health Organization estimates that over 40 million people are infected with HIV/AIDS. Emerging resistance to current antiretroviral treatments accentuates the need for the developing of new drugs aimed at targets other than the traditional ones. Among the new classes of drugs, the HIV viral entry inhibitors are especially promising since they target protein complexes involved in viral membrane fusion. BMS-806, a small molecule drug candidate that binds to the HIV-1 envelope protein gp120, has shown to be a potent and specific HIV-1 viral entry inhibitor. This research is designed to gain a fundamental understanding of the molecular mechanism of binding BMS-806 to the envelope glycoprotein gp120 in order to identify the chemical and structural determinants of its antiviral activity.

Event Info

Sponsored By:
Department of Chemistry and Biochemistry

Contact Information:
Fern Cardella
fcardel7@naz.edu
585-389-2667

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