CHED Irvin Levy, Carmen Gauthier, Nicole Snyder  Monday, April 8, 2013 

1108 - Structural analysis of HIV-1 inhibitor drug candidate BMS-378806: The role of benzyl derivatives

McKenna Murphy, mmurph65@naz.edu, Emily Triplett, ejt258@gmail.com, Stephen Tacj. Chemistry, Nazareth College of Rochester, Rochester, NY 14618, United States

Since the discovery of HIV in 1981, AIDS has caused the deaths of millions of people. The current treatment requires high dosages and results in unfavorable side effects that discourage long-term use. BMS-378806 is a small molecule HIV-1 inhibitor that is preferable to the current therapy. However, little is known about the mechanism of this drug. This research aims to identify the most effective functional groups by attaching structural variations to the piperzine-adjacent phenyl ketone. These structural variants may be analyzed by isothermal titration calorimetry (ITC) to determine thermodynamically favorable binding conditions. This data may be used to construct an even more effect HIV-1 inhibitor.



Monday, April 8, 2013 12:00 PM
Undergraduate Research Posters (12:00 PM - 02:30 PM)
Location: Morial Convention Center
Room: Hall D

 

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