CHED Irvin Levy, Carmen Gauthier, Nicole Snyder  Monday, April 8, 2013 

1083 - Modifying small molecule BMS-806 to bind glycoprotein gp120 on solid surface

Moudi Hubeishy,, Stephen Tajc. Biochemistry and Chemistry, Nazareth College Of Rochester, Rochester, NY 14618, United States

HIV infection continues to be a prevalent stress in the nation. About 1.2 million people are living with HIV in the United States but approximately 240,000 are unaware of their infection. The Center for Disease Control and Prevention (CDC) is studying to rapidly screen for HIV by using antibodies.1 However, antibodies are large proteins that cost more and are less stable than small molecules, we are interested in using a small molecule drug that is proven to bind to the HIV-1 envelope glycoprotein gp120 such as that of BMS-806.2 In this research, we explore the addition of a synthetic linker to create an amine on the 7-azaindole portion of BMS-806 in solution. This amine will allow us to covalently attach a linker to BMS-806. The linker will allow for solid surface binding analysis so then we might have more information about how the HIV-1 viral protein interacts with small molecules.

Monday, April 8, 2013 12:00 PM
Undergraduate Research Posters (12:00 PM - 02:30 PM)
Location: Morial Convention Center
Room: Hall D


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